Dupuytren's disease is a common and disabling fibroproliferative condition of the hand, which may progress slowly over time to Dupuytren's contracture.

Increased collagen production and deposition causes pitting and thickening of the palmar skin, along with the development of painless nodules fixed to the skin and deeper fascia. Classically, a nodule precedes the development of a cord.

Over time, the cord gradually contracts, reeling in the metacarpophalangeal joint and the proximal interphalangeal joint and leading to progressive digital flexion deformity – primarily of the ring (4th) and little (5th) fingers.

Progression to Dupuytren's contracture

The resulting inability to fully extend the affected fingers and reduction in range of motion, can be psychosocially and physically disabling for the patient.

The condition is commonly bilateral and often associated with other areas of the body, such as Garrod's knuckle pads (44–54%), plantar fibromatosis (Ledderhose disease, 6–31%), and penile fibromatosis (Peyronie's disease, 2–8%).

There is no cure for Dupuytren’s but there are effective treatment options which can improve the lives of patients with Dupuytren’s.

References

  1. Townley WA et al. BMJ 2006; 332:397–400.
  2. Bayat A et al. Ann R Coll Surg Engl 2006; 88:3–8.
  3. Hindocha S et al. Hand 2009; 4:256–69.